Periodontal Disease and Oral Health

MEDLINE EXPRESS (R) 1/96-10/96 11 of 469

TI: Coenzyme Q10 and periodontal disease [letter]
AU: Lister-RE
SO: Br-Dent-J. 1995 Sep 23; 179(6): 200-1

MEDLINE EXPRESS (R) 1991-1995 44 of 469

TI: Coenzyme Q10 and periodontal treatment: is there any beneficial effect?
AU: Watts-TL
SO: Br-Dent-J. 1995 Mar 25; 178(6): 209-13
AB: Many dentists have been surprised by recent media claims of periodontal benefits with a purportedly revolutionary dietary supplement. The research literature on  coenzyme Q10's periodontal effects does not extend to the international English language dental literature, which perhaps explains the surprise. A review of the available literature does not give any ground for the claims made, and selected papers are discussed to show that there is actually some evidence that coenzyme Q10 has no place in periodontal treatment.

MEDLINE EXPRESS (R) 1991-1995 61 of 469

TI: Effect of topical application of coenzyme Q10 on adult periodontitis.
AU: Hanioka-T; Tanaka-M; Ojima-M; Shizukuishi-S; Folkers-K
SO: Mol-Aspects-Med. 1994; 15 Suppl: s241-8
AB: Topical application of Coenzyme Q10 (CoQ10) to the periodontal pocket was evaluated with and without subgingival mechanical debridement. Ten male patients with adult periodontitis participated and 30 periodontal pockets were selected. During the first 3 weeks, the patients did not receive any periodontal  therapy except the topical application of CoQ10. After the first 3-week period, root planning and subgingival scaling were performed in all sites. CoQ10 was applied in 20 of the pockets once a week for a period of 6 weeks. Soybean oil was applied to the remaining 10 sites as a control. In the first 3-week period, significant reductions in gingival crevicular fluid flow, probing depth and attachment loss were found only at experimental sites. After mechanical subgingival debridement,  significant decreases in the plaque index, gingival crevicular fluid flow, probing depth and attachment loss were found both at experimental and control sites. However, significant improvements in the modified gingival index, bleeding on probing and peptidase activity derived from periodontopathic bacteria were observed only at experimental sites. These results suggest that topical application of CoQ10 improves adult periodontitis not only as a sole treatment but also in combination with  traditional nonsurgical periodontal therapy.